Our research focus

 

Our group is interested in the causes and consequences of mitochondrial DNA instability, especially how mitochondrial DNA instability is signaled to the rest of the cell. We use a combination of in vitro biochemistry, mammalian cell culture and yeast genetics to explore the basic mechanisms that ensure the maintenance of this small but (in most organisms) essential genome. 

Latest Posts

  • Lab preprints out!
    March 17, 2024 No Comments Check out some of our latest work that is now available as preprints on bioRxiv: How AMPK activation can help ameliorate the pathological effects of mtDNA-related disease, with contributions by Gustavo, Bruno, Tran, Josefin, Isabela, Mara and great collaborations with both the Hofer lab (Farah and Anders) and the Pitceathly lab (Micol and Robert). Thanks

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  • Last chance (?) to work on mitochondrial interactions with pathogens
    March 17, 2024 No Comments We are looking for a driven postdoc candidate to spearhead an ambitious and interdisciplinary research project on the interaction of mitochondria with the intracellular pathogen Chlamydia trachomatis. The selected candidate of this KBC postdoc call will gain access to the expertise and support of both our lab and that of the Sixt lab with their

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  • Unique postdoc opportunity!
    September 22, 2023 No Comments If you are interested in mito-pathogen interactions during bacterial infection, this is something for you: together with the Sixt lab, we now offer a postdoc opportunity in a collaborative project to uncover the role of mitochondrial (dys)function during infection by Chlamydia trachomatis infection. Due to its intracellular lifestyle, Chlamydia is dependent on the host cell

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