Our research focus
Our group is interested in the causes and consequences of mitochondrial DNA instability, especially how mitochondrial DNA instability is signaled to the rest of the cell. We use a combination of in vitro biochemistry, mammalian cell culture and yeast genetics to explore the basic mechanisms that ensure the maintenance of this small but (in most organisms) essential genome.
Latest Posts
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Topoisomerase paper accepted!
We are proud to announce that the work of Cyrielle, Erika and others on the differences of the human nuclear and mitochondrial Topoisomerase 1 enzymes is now accepted in Nucleic Acids Research! A big thanks to everyone involved: Cyrielle, Erika, Josefin, Aiswarya and Gosia. Also fun that all authors are from our own lab.In thisRead More -
Two articles in one PNAS issue
Check out the latest issue of PNAS that contains two (2!) very interesting articles on mtDNA stability that we contributed to: Awoyomi OF, Gorospe CM, Das B, Mishra P, Sharma S, Diachenko O, Nilsson AK, Tran P, Wanrooij PH†, Chabes A†.RRM2B deficiency causes dATP and dGTP depletion through enhanced degradation and slower synthesis. Forslund JME,Read More -
Postdoc opportunity!
Are you passionate about mitochondria and mitochondrial DNA? We now offer a 2-year postdoc fellowship for studies of mtDNA stability and/or retrograde signaling. Join our international team in beautiful Umeå, and apply by May 18th at the latest! More info & application here.