PUBLICATIONS

Article titles link to the full-text articles.

2023

Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression.
Gorospe CM, Carvalho G, Herrera Curbelo A, Marchhart L, Mendes IC, Niedzwiecka K and Wanrooij PH (2023)
Life Science Alliance, 6(12). https://doi.org/10.26508/lsa.202302091

NME6: ribonucleotide salvage sustains mitochondrial transcription.
Wanrooij PH and Chabes A (2023)
EMBO Journal, Aug 7:e114990. https://doi.org/10.15252/embj.2023114990

Determination of the ribonucleotide content of mtDNA using alkaline gels.
In Methods in Molecular Biology: Mitochondrial DNA.
Gorospe CM, Repolês BM and Wanrooij PH (2023)
Springer Nature. Edited by Thomas Nicholls, Jennifer Uhler and Maria Falkenberg.
https://link.springer.com/protocol/10.1007/978-1-0716-2922-2_21                                    

2022

Mitochondrial DNA instability in mammalian cells.
Carvalho G*, Repolês BM*, Mendes I and Wanrooij PH (2022).
Antioxidant and Redox Signaling, https://doi.org/10.1089/ars.2021.0091 (online in 2021)
*Equal contribution.

2021

The integrity and assay performance of tissue mitochondrial DNA is considerably affected by choice of isolation method.
Repolês BM, Gorospe CM, Tran P, Nilsson AK and Wanrooij PH (2021).
Mitochondrion, 61:179-187.

2020

MtDNA replication, maintenance and nucleoid organization.
In The human mitochondrial genome: From basic biology to disease.
Doimo M, Pfeiffer A, Wanrooij PH† and Wanrooij S† (2020).
https://doi.org/10.1016/C2019-0-00035-0
†Co-last authorship.

Elimination of rNMPs from mitochondrial DNA has no effect on its stability.
Wanrooij PH†, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR, Chabes A† (2020).
PNAS, 117(25):14306-14313.    
†Co-corresponding author.

2019

Ribonucleotides in mitochondrial DNA.
Wanrooij PH†, Chabes A† (2019).
FEBS Lett, 593(13):1554-65.
†Co-corresponding author.
      

De novo dNTP production is essential for normal postnatal murine heart development.
Tran P, Wanrooij PH, Lorenzon P, Sharma S, Thelander L, Nilsson AK, Olofsson AK, Medinin P, von Hofsten J, Stål P, Chabes A (2019).
JBC, 294(44), pp. 15889-15897.   

2018

Inosine triphosphate pyrophosphatase dephosphorylates ribavirin triphosphate and reduced enzymatic activity potentiates mutagenesis in hepatitis C virus.
Nyström K, Wanrooij PH, Waldenström J, Adamek L, Brunet S, Said J, Nilsson S, Wind-Rotolo M, Hellstrand K, Norder H, Tang KW, Lagging M (2018).
J Virol, pii: JVI.01087-18.          

The presence of rNTPs decreases the speed of mitochondrial DNA replication.
Forslund JME, Pfeiffer A, Stojkovic G, Wanrooij PH, Wanrooij S (2018).
PLOS Gen, 14, e1007315.    

2017

Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired.
Wanrooij PH†, Engqvist MKM#, Forslund JME#, Navarrete C, Nilsson AK, Sedman J, Wanrooij S, Clausen AR, Chabes AC† (2017).
PNAS, 114: 12466-71.    
†Co-corresponding author. #Equal contribution.


DNA damage tolerance by eukaryotic DNA polymerase and primase PrimPol.
Boldinova EO†, Wanrooij PH†, Shilkin ES, Wanrooij S, Makarova AV (2017).
Int J  Mol Sci,18: pii: E1584.  
†Equal contribution.

2016

Oxidative DNA damage stalls the human mitochondrial replisome.
Stojkovic G, Makarova AV, Wanrooij PH, Forslund J, Burgers PM, Wanrooij S (2016).
Sci Rep, 6: 28942.          


The dimeric architecture of checkpoint kinases Mec1ATR and Tel1ATM reveal a common organization.
Sawicka M†, Wanrooij PH†, Darbari VC†, Tannous E, Hailemariam S, Bose D, Makarova AV, Burgers PM, Zhang X (2016).
JBC, 291: 13436-47.     
†Equal contribution.


Probing the Mec1/ATR checkpoint activation mechanism with small peptides.
Wanrooij PH, Tannous E, Kumar S, Navadgi-Patil VM, Burgers PM (2016).
JBC, 291: 393-401.  

2015

Yet another job for DNA2: checkpoint activation.  
Wanrooij, PH, Burgers, PM (2015).  
DNA Rep, 32: 17-23.       
     

2012

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery.
Shi Y, Dierckx A, Wanrooij PH, Wanrooij S, Larsson NG, Wilhelmsson LM, Falkenberg M, Gustafsson CM (2012).
PNAS, 109: 16510-5.           


A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop.
Wanrooij PH, Uhler JP, Shi Y, Westerlund F, Falkenberg M, Gustafsson CM (2012).
NAR, 40: 10334-44.           


In vivo mutagenesis reveals that OriL is essential in mammals.
Wanrooij S, Miralles Fusté J, Stewart JB, Wanrooij PH, Samuelsson T, Larsson NG, Gustafsson CM, Falkenberg M (2012).
EMBO Rep,13: 1130-7.  

2010

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation.
Wanrooij PH, Uhler JP, Simonsson T, Falkenberg M, Gustafsson CM (2010).
PNAS, 107: 16072-7.   


A chromatin remodeling protein is a component of fission yeast mediator.
Khorosjutina O, Wanrooij PH, Walfridsson J, Szilagyi Z, Zhu X, Baraznenok V, Ekwall K, Gustafsson CM (2010).
JBC, 285: 29729-37. 

2007

A genome-wide role for CHD remodeling factors and Nap1 in nucleosome disassembly.
Walfridsson J, Khorosjutina O, Matikainen P, Gustafsson CM, Ekwall K (2007).
EMBO J, 26, 2868-2879.